Lobophorins

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August undefined, 2024

Witryna1 lip 2024 · Lobophorins H and I did not exhibit inhibitory activity against Gram-negative bacteria (E. coli) and fungi (C. albicans and F. moniliforme), whereas lobophorin H and lobophorin F showed moderate inhibitory activities against Staphylococcus aureus ATCC 29213 with the MIC values of 50 and 6.25 μg/mL, respectively. Witryna1 kwi 2024 · from Peruvian marshes were lobophorins A (1) and H (2), as well as divergolides A (3), B (4) and C (5). Streptomyces sp. 796.1 produced different compounds, such as glucopiericidin A (6) and dehy-dro-piericidin A1a (7). The search for new metabolites in underexplored environments may there-

Cloning and identification of the lobophorin biosynthetic gene …

Witryna13 lis 2013 · Lobophorins belong to a family of bacterial spirotetronates, which comprise a large class of antibiotics and antitumor agents. In addition to lobophorins, 18 – 20 the family includes antlermicins, 24 , 25 chlorothricin, 26 kijanimicin, 27 decatromicins, 28 saccharocarcins, 29 tetrocarcins, 30 and versipelostatins. 31 The mechanism of action ... WitrynaStructure and activity of lobophorins from a turrid mollusk-associated Streptomyces sp cpvc blast gate

Cloning and identification of the lobophorin ... - Semantic Scholar

Witryna19 lip 1999 · Two new antiinflammatory macrolides, lobophorins A and B (1 and 2), have been isolated from fermentation broths of a marine bacterium isolated from the surface the Caribbean brown alga Lobophora variegata (Dictyotales).The new compounds, distantly related to antibiotics of the kijanimicin class, are potent … WitrynaComplementary Cell-Based High Throughput Screens Identify Novel Modulators of the Unfolded Protein Response . Despite advances toward understanding the prevention and treatment of many cancers, patients who suffer from oral squamous cell carcinoma (OSCC) confront a survival rate that has remained unimproved for more than two … Witryna20 lip 2013 · Lobophorins (LOB) A (1)a n dB(2)(F i g. 1)a r em e m b e r so fa. large class of spirotetronate antibiotics, which feat ure a. tetronate moiet y with a sp ir o-link ag e to a cycl ohe xen e ring ... cpvc ced.80

(PDF) Characterization of the sugar-O-methyltransferase LobS1 …

WitrynaThe zinc finger proteins Mig1 and Mig2 play important roles in glucose repression of Saccharomyces cerevisiae. To investigate whether the alleviation of glucose effect would result in an increase in aerobic succinate production, MIG1 and/or MIG2 were disrupted in a succinate dehydrogenase (SDH)-negative S. cerevisiae strain. Moreover, their … cpvc brittleness ageWitrynaIn turn, from L. totopotens we cultivated a Streptomyces sp. strain that contained new and known spirotetronate polyketides, lobophorins (1–5). The structures were elucidated using spectroscopy, and the compounds were evaluated for cytotoxicity to human cells and activity against Mycobacterium tuberculosis, Bacillus subtilis, … distinguishing property of kaolinite

"WitrynaStrain 12A35 was isolated from a deep-sea sediment collected from the South China Sea and showed promising antibacterial activities. It was identified as Streptomyces sp. by … " - Lobophorins

Lobophorins

WitrynaM. C. Sullards, J. Kubanek, P. Jensen, 2003, Proceedings of the National Academy of Sciences of the United States of America. Witryna

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Witryna深海一般指水深1000米以下的海洋，具有高压、低温（或高温）、黑暗、寡营养和高盐等特征，原本被认为是生命的荒漠。随着人类开发海洋技术的 ... Witryna8 wrz 2024 · Lobophorins were discovered by Jiang et al. (1999) in the expedition to Belize on board the Columbus research ship . On the occasion, a new strain of actinomycete, named # CNC-837, was isolated from the surface of a brown algae from the Caribbean called Lobophora variegata , and was reported to produce …

Witrynathe lobophorins in this study indicated that the more substitution number of the sugar moieties at C-9 of the lobophorin, the stron-ger antimicrobial properties it may deserve, and the higher the oxidation degree of substituent group at C-3 D, the better antibac-terial activities of its corresponding compound could be. ARTICLE HISTORY Witryna7 wrz 2011 · The strain SCSIO 01127, isolated from the South China Sea sediment, was identified as a member of Streptomyces by the 16S rDNA sequence analysis. Two …

WitrynaThe strain belongs to the genus Streptomyces according to its morphological and 16S rDNA phylogenetic analysis. Bioassay-guided isolation resulted in a new spirotetronate, lobophorin G (1), together with two known compounds, lobophorins A (2) and B (3). The structures were elucidated by extensive spectroscopic methods and comparison with ... Witryna15 paź 2013 · One representative of this group is lobophorins, among which lobophorins A and B were produced from an alga-associated acintobacterium , …

WitrynaA full length about 105 kb gene cluster containing 35 open reading frames involved in the biosynthesis of lobophorins was cloned and sequenced from a fosmid genomic …

WitrynaThe study of a symbiotic Streptomyces sp. (strain 1053U.I.1a.3b) of cone snails lead to the isolation of two lobophorins, H and I . Lobophorins are a large family of spirotetronates with antimicrobial and cytotoxic bioactivities. Of these, lobophorin I (61) showed potent cytotoxic activity against human T-cell leukaemia cell line CEM-TART. cpvc brittlenessWitrynaThe endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins which are detected by ER transmembrane receptors that initiate the unfolded protein response (UPR) to restore normal ER … distinguishing property of biotiteWitrynaThe antibacterial activities of the lobophorins in this study indicated that the more substitution number of the sugar moieties at C-9 of the lobophorin, the stronger antimicrobial properties it may deserve, and the higher the oxidation degree of substituent group at C-3 D, the better antibacterial activities of its corresponding … distinguishing property of dolomiteWitryna19 lip 1999 · Lobophorins A and B are potent antiinflammatory agents when applied topically or administered IP in a whole animal model. Actinomycete strain # CNB-837 … distinguishing property of gabbroWitryna20 lip 2013 · Lobophorins A (1) and B (2) belong to a large group of spirotetronate natural products with potent antibacterial and antitumor activities. The cloning of the lobophorin biosynthesis gene cluster from the deep-sea-derived Streptomyces sp. SCSIO 01127 identified a sugar-O-methyltransferase-encoding gene lobS1. The lobS1 … distinguishing property of hydroxyapatiteWitryna11 cze 2024 · Two new antiinflammatory macrolides, lobophorins A and B (1 and 2), have been isolated from fermentation broths of a marine bacterium isolated from the surface the Caribbean brown alga Lobophora variegata (Dictyotales). The new compounds, distantly related to antibiotics of the kijanimicin class, are potent … cpvc cement drying timeIn the course of a screening program for bioactive compounds from a marine natural product library, a newly isolated Actinomycetes strain, designated as MS100061, exhibited strong anti-Mycobacterium bovis Bacillus Calmette–Guérin (BCG) activity. The strain belongs to the genus Streptomyces according to its … distinguishing property of slate