Sumo ythdf2

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August undefined, 2024

Web23 Jun 2024 · This motivated us to study YTHDF2 in NK cells using a conditional knockout approach. We show that depletion of Ythdf2 in mouse NK cells significantly impaired NK … Web8 Apr 2024 · The N6-methyladenosine (m6A) modification regulates mRNA stability and translation. Here, we show that transcriptomic m6A modification can be dynamic and the m6A reader protein YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) promotes mRNA decay during cell cycle. Depletion of YTHDF2 in HeLa cells leads to the delay of …

SUMOylation of YTHDF2 promotes mRNA degradation and cancer

Web9 Nov 2024 · One key function of YTHDF2 is to bind to the m6A chemical modification on mRNA and promote degradation. Our work demonstrating that YTHDF2 downregulates the activity of pro-inflammatory genes, may establish a paradigm whereby m6A mRNA modification regulates inflammatory pathways in blood and also other tissue stem cells. WebSUMOylation of YTHDF2 was confirmed by the method of immunoprecipitation (IP). HA-YTHDF2 with or without His-SUMO1 and Flag-Ubc9 were co-transfected into the 293T … farms for sale in breckinridge county ky

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Web21 Nov 2014 · YTHDF2 is also known to be involved in development of acute myeloid leukemia 12. YTHDC1 (splicing factor YT521-B), another YTH domain-containing protein, … WebThis gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in … WebDianova’s development programme aimed at providing better antibodies for tumor diagnostics redefines antibody performance in immunohistochemistry (IHC). free screen recording software sharex

The RNA m6A reader YTHDF2 is essential for the post …

The RNA m6A reader YTHDF2 controls NK cell antitumor …

WebWe therefore evaluated the expression pattern of YTHDF2 in NK cells during murine cytomegalovirus (MCMV) infection. Using the GEO database, we found that Ythdf2 was upregulated at day 1.5 post-infection in two independent databases (Fig. 1 G and Fig. S1 D). An immunoblotting assay confirmed that the protein levels of YTHDF2 were also Web21 Mar 2024 · YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein F2) is a Protein Coding gene. Diseases associated with YTHDF2 include Myeloid Leukemia and Ocular … farms for sale in brazoria countyWeb18 Mar 2024 · YTHDF2 was modified by SUMO1 with a size of Mr ∼95–100 kDa (the expected normal size of YTHDF2 is 70 kDa), which is YTHDF2 covalently conjugated with … farms for sale in brock township ontario

"Web21 Mar 2024 · YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein F2) is a Protein Coding gene. Diseases associated with YTHDF2 include Myeloid Leukemia and Ocular Melanoma . Gene Ontology (GO) annotations related to this gene include RNA binding and N6-methyladenosine-containing RNA binding . An important paralog of this gene is YTHDF3. " - Sumo ythdf2

Sumo ythdf2

YTHDF2 is SUMOylated in vitro and in vivo. (A, B) YTHDF2 …

WebYTH domain family, member 2 [Source:HGNC Symbol;Acc: 31675] Gene Synonyms HGRG8, NY-REN-2 Location Chromosome 1: 29,063,271-29,096,287 forward strand. About this transcript This transcript has 5 exons, is annotated with 7 domains and features, is associated with 10632 variant alleles and maps to 405 oligo probes. Gene WebYTHDF2 was transferred into SW1990 and PaTu8988 cells, and then YTHDF2 overexpression was examined at mRNA by real-time PCR (Fig. S1A). Unexpectedly, no signiﬁcant changes in the level of protein were observed in YTHDF2 overexpres-sion group (Fig. S1B). Subsequently, we identiﬁed plasmids Vector and Flag-YTHDF2 in H293T cell, …

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WebThe loss of YTHDF2 results in the failure to regulate transcript dosage of a cohort of genes during oocyte maturation, with enrichment observed for the YTHDF2-binding consensus and evidence of m6A in these upregulated genes. In summary, the m6A-reader YTHDF2 is an intrinsic determinant of mammalian oocyte competence and early zygotic development.", WebYTHDF2 deficiency in TAMs suppressed tumor growth by reprogramming TAMs toward an antitumoral phenotype and increasing their antigen cross-presentation ability, which in …

Web3 Mar 2024 · National Center for Biotechnology Information WebHigh expressions of both YTHDF1 and YTHDF2 are associated with a favorable prognostic outcome of NSCLC patients, a greater amount of TILs, and downregulation of PD-L1. …

Web13 Jun 2024 · The currently confirmed readers include YTH domain proteins (YTHDF1, YTHDF2, YTHDF3, YTHDC1 and YTHDC2) and HNRNP family proteins. 12 Among them, YTH domain family 2 (YTHDF2) is the most effective m 6 A reader, exhibiting a series of biological processes involved in cancer carcinogenesis. 14 As a main cytoplasm m 6 A … Web29 Oct 2024 · YTHDF2 was frequently overexpressed in AML, and the m 6 A modified apoptosis-induced gene TNFRSF2 was targeted by YTHDF2 to decrease its half-life, which …

WebThe lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃. ***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm.

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